A Quantitative Theory of the Precipitin Reaction

Quantitative Studies on the Precipitin Reaction Effect of Salts on the P~eaction*

In the studies on the precipitin reaction hitherto published from this laboratory (1) the salt concentration was held constant at 0.9 per cent of sodium chloride in order to permit observations on the effect of varying the proportions of antigen (or hapten) and antibody. In the present paper are reported data obtained during several years on the influence on the course of the precipitin reactio...

Quantitative Studies on the Precipitin Reaction Effect of Salts on Tee Reaction*

In the studies on the precipitin reaction hitherto published from this laboratory (1) the salt concentration was held constant at 0.9 per cent of sodium chloride in order to permit observations on the effect of varying the proportions of antigen (or hapten) and antibody. In the present paper are reported data obtained during several years on the influence on the course of the precipitin reactio...

ALBUMIN-ANTIBODY REACTION IN ANTISERA FROM THE RABBIT AND HORSE* BY MICHAEL HEIDELBERGER, P-.D., HENRY P. TREFFERS, PH.D., ANn

In Paper I I I of this series (1) it was shown that the quantitative theory of the precipitin reaction (2) was applicable to the reaction between a native protein, crystalline egg albumin? and its homologous antibodies in the rabbit. Data were also given for the sera from a single rabbit after three successive courses of injections. I t was found that in the linear equation characterizing the b...

A Quantitative Study of the Cross Reaction of Types Iii and Viii Pneumococci in Horse and Rabbit Antisera

1. A preparation of the specific polysaccharide of Type VIII pneumococcus is described in which the use of heat, strong acid, and alkali were avoided. 2. Quantitative estimations are given of the homologous and cross reacting precipitin and agglutinin in Types III and VIII antisera produced in the rabbit and in the horse. Quantitative data are also given on the mechanism of the Type VIII precip...

On the Possible Importance of Colloidal Protection in Certain Phases of the Precipitin Reaction

It 'has been frequently observed by those who have worked with l:he precipitin reaction that the sera of protein-immunized animals may contain, at certain times, both precipitin, and, side by side with it, unassimilated remnants of the antigen. Such sera, w'hen taken, are clear, but will show precipitation not only when mixed with dihttions of the antigen, but also when added to other homologou...

The antigen-antibody reaction. I. The influence of sodium chloride concentration on the quantitative precipitin reaction.